数字电子技术实验“线上-线下混合”教学改革

在“移动互联网+课堂”的大势趋动下,针对现在“数字电子技术实验”教学存在的教学模式落后,教学手段单一,教学内容简单、以及考核不够全面等问题,借助超星泛雅 “一平三端”平台进行“线上-线下混合教学”改革。通过课前发布任务、课中有效组织课堂活动、课后发布作业、统计数据和教学反思进行。实践表明：该方法提高了学生的自主学习能力,并且增强了教师对学生学习情况的动态跟踪和过程性指导,同时也让课堂教学更有效,教学评价方式更有针对性、更精准,最终达到知识、技能和情感态度价值观的培养。     

Acceptive Immunity: The Role of Fucosylated Glycans in Human Host–Microbiome Interactions

The growth in the number of chronic non-communicable diseases in the second half of the past century and in the first two decades of the new century is largely due to the disruption of the relationship between the human body and its symbiotic microbiota, and not pathogens. The interaction of the human immune system with symbionts is not accompanied by inflammation, but is a physiological norm. This is achieved via microbiota control by the immune system through a complex balance of pro-inflammatory and suppressive responses, and only a disturbance of this balance can trigger pathophysiological mechanisms. This review discusses the establishment of homeostatic relationships during immune system development and intestinal bacterial colonization through the interaction of milk glycans, mucins, and secretory immunoglobulins. In particular, the role of fucose and fucosylated glycans in the mechanism of interactions between host epithelial and immune cells is discussed.     

Role of ABCA7 in Human Health and in Alzheimer’s Disease

Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer’s disease (AD). This ABC transporter is now considered as an important genetic determinant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.     

Combinations of Piperine with Hydroxypropyl-β-Cyclodextrin as a Multifunctional System

Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition. Low solubility and the associated low bioavailability of piperine limit its potential. The combination of piperine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood–brain barrier. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-β-CD. The observed physicochemical changes should be combined with the process of piperine and CD system formation. Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase).     

Preparation and electrical conductivity of KTaO3-based proton conductor

KTaO₃ and KTa_0.9M_0.1O_3-α (M = Ti, Hf, Zr) were prepared by solid state reaction at 1330 °C for 2 h and characterized by x-ray diffraction. The AC impedance technique was used to analyze the sintered solid electrolytes in 1%H₂/Ar and dry air atmosphere. Among KTa_0.9M_0.1O_3-α (M = Ti, Hf, Zr), KTa_0.9Zr_0.1O_3-α displays the highest conductivity in 1%H₂/Ar atmosphere. The carriers transport numbers of solid electrolytes were measured by concentration cell method. The results show KTa_0.9Zr_0.1O_3-α is a pure proton conductor below 525 °C. Stability tests show that KTa_0.9Zr_0.1O_3-α has good chemical stability against CO₂ and H₂O.